The term “entourage effect” was first coined by Dr. Raphael Mechoulam, a leading researcher and professor of Medicinal Chemistry at the Hebrew University of Jerusalem, in his 1999 study “Cannabis – The Israeli Perspective”. Dr. Mechoulam is widely recognized as one of the pioneering researchers in the study of cannabis and the endocannabinoid system. He said the entourage effect refers to the idea that the combination of multiple compounds in a plant or combined from different plants can have a synergistic effect that is greater than the sum of their individual effects. In other words, when certain compounds are combined, they can work together to not only enhance each other’s therapeutic effects, but also modulate and reduce unwanted side effects.
Dr. Raphael Mechoulam THE ENTOURAGE EFFECT pioneering researcher
The entourage effect is a phenomenon which explains where the various compounds in a plant work synergistically to create unique therapeutic effects. One of the first plants in Western culture to have been identified to have an entourage effect is cannabis. While tetrahydrocannabinol is often considered the primary active compound in cannabis, research suggests that the presence of other compounds, such as cannabidiol and terpenes also modify and enhance the therapeutic efficacy of the plant.
The entourage effect has been observed in traditional Chinese herbal formulas for thousands of years, however it remains a topic of ongoing research and debate in the scientific community. The concept of the entourage effect is particularly relevant to TCM herbal formulas, which is where I learned about this synergistic effect of nutritive substances. In Oriental herbal traditions the herbal formulas often contain multiple herbs that are combined in specific ratios to create a balanced formula. The different herbs in a formula may contain many different active compounds, such as alkaloids, flavonoids, polyphenols, sterols, minerals, vitamins, or terpenes, that can interact with each other to produce a more powerful therapeutic effect by directing herbal actions toward certain organs and systems of the body.
Dr. Raphael Mechoulam THE ENTOURAGE EFFECT pioneering researcher
The entourage effect is a phenomenon which explains where the various compounds in a plant work synergistically to create unique therapeutic effects. One of the first plants in Western culture to have been identified to have an entourage effect is cannabis. While tetrahydrocannabinol is often considered the primary active compound in cannabis, research suggests that the presence of other compounds, such as cannabidiol and terpenes also modify and enhance the therapeutic efficacy of the plant.
The entourage effect has been observed in traditional Chinese herbal formulas for thousands of years, however it remains a topic of ongoing research and debate in the scientific community. The concept of the entourage effect is particularly relevant to TCM herbal formulas, which is where I learned about this synergistic effect of nutritive substances. In Oriental herbal traditions the herbal formulas often contain multiple herbs that are combined in specific ratios to create a balanced formula. The different herbs in a formula may contain many different active compounds, such as alkaloids, flavonoids, polyphenols, sterols, minerals, vitamins, or terpenes, that can interact with each other to produce a more powerful therapeutic effect by directing herbal actions toward certain organs and systems of the body.
For example, one herb in a formula may have anti-inflammatory properties, while another herb may have antioxidant properties. When these herbs are combined, their anti-inflammatory and antioxidant effects may work together to produce a more potent anti-inflammatory effect than either herb would have on its own. Additionally, the entourage effect can help to minimize any potential side effects of individual herbs by balancing out their effects and enhancing their overall therapeutic value. This is why herbal practitioners traditionally use complex herbal formulas instead of single herbs to treat complex conditions.
The entourage effect is an important consideration in using herbal formulas and using MitoBolic Blue, as it can aid the mitochondria in ailing areas of the body to move electrons efficiently which helps the different herbs in a formula to work together to produce synergistic and balanced therapeutic effects.
To tie it together with MitoBolic Blue, the entourage effect works because the various nutrients can go together through the system unlocking each of their particular benefits as they help the formula to achieve a greater effect than the components could have created alone. In our formulas we use nutrients combined with MitoBolic Blue to support the areas of your body so that your cells can create the healing you need from within.
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